Your gemstones will need occasional attention to keep them beautiful.  Many are porous and should not be soaked in water for any extended period of time. I do not recommend your stones come into contact with household cleaners.  They should not be worn in chlorine or salt water.  Always remove your jewelry when taking a shower to avoid contact with cleansers or lotions. 

When you do need to clean your gemstones use a mild liquid soap.  Rub gently with a cotton cloth, rinse with warm water and pat dry.  Allow to air dry.